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. 2020 Feb 25;30(8):2567–2580.e6. doi: 10.1016/j.celrep.2020.01.105

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© 2020 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Increased Rate of Detected Calcium Events in SLS

(A) Left: rate of detected calcium events in anesthetized animals under the different conditions. Right: rate of detected events with downsampling of SLS to match the acquisition rate of raster scanning. Spontaneous activity: n = 6 for raster, n = 6 for SLS at 0–20 Hz, n = 6 for SLS at 20–40 Hz, n = 3 for SLS at >40 Hz from 6 anesthetized mice. Left: paired t test, p = 0.32 for raster versus SLS 0–20 Hz, p = 4E-3 for raster versus SLS 20-40 Hz; unpaired t test, p = 1E-4 for raster versus SLS >40 Hz. Right: paired t test, p = 0.02 for raster versus SLS 0–20 Hz, p = 1E-4 for raster versus SLS 20–40 Hz; unpaired t test p = 1E-4 for raster versus SLS >40 Hz. Air puff stimulation: n = 20 for raster, n = 15 for SLS at 0–20 Hz, n = 13 for SLS at 20–40 Hz, n = 7 for SLS at >40 Hz from 6 anesthetized mice. Left: unpaired t test, p = 0.01 for raster versus SLS 0–20 Hz, p = 1E-4 for raster versus SLS 20–40 Hz, p = 1E-4 for raster versus SLS >40 Hz. Right: unpaired t test, p = 1E-4 for raster versus SLS 0–20 Hz, p = 3E-6 for raster versus SLS 20–40 Hz, p = 6E-8 for raster versus SLS >40 Hz.

(B) Same as in (A) for awake mice. Spontaneous activity: n = 5 for raster and n = 4 for SLS at 0–20 Hz from 2 awake mice. Unpaired t test, p = 4E-6 and p = 9E-6 for left and right panels. Air puff stimulation: n = 7 for raster and n = 8 for SLS at 0–20 Hz from 2 awake mice. Unpaired t test, p = 2E-8 and p = 6E-8 for left and right panels.

(C) Normalized amplitude of events under the different conditions in anesthetized mice. Same dataset as in (A). Spontaneous activity: paired t test, p = 6E-8 for raster versus SLS 0–20 Hz, p = 6E-8 for raster versus SLS 20–40 Hz; unpaired t test, p = 6E-8 for raster versus SLS >40 Hz. Air puff stimulation: unpaired t test, p = 6E-8 for raster versus SLS 0–20 Hz, p = 6E-8 for raster versus SLS 20–40 Hz, p = 6E-8 for raster versus SLS >40 Hz.

(D) Same as in (C) for awake mice. Number of acquisitions for each condition as in (B). Spontaneous activity: unpaired t test, p = 2E-6. Air puff stimulation: unpaired t test, p = 1E-7.