Table 5. GRADE-assessment: Secondary prevention: interventions to support children and adolescents bereaved or affected by a suspected suicide versus treatment as usual (TAU) or historical control.
| Population: Children and adolescents in primary and secondary school (under the age of 17) that have lost a friend or parent to
suspected suicide Intervention: Interventions to support children and adolescents bereaved or affected by a suspected suicide Control: TAU or historical Based on: NICE 2018 | ||||
|---|---|---|---|---|
| Outcomes | Studies (number of
participants) |
Effect estimates in
control group |
Effect estimates in
intervention group |
Quality of
evidence (GRADE) |
|
Suicides – 3-year follow-up period
|
1 study (89 participants) | 3 per 270 (in the
study they counted the whole school- population) |
0 per 270;
RR 0.14 (95% KI 0.01 to 2.75) |
⊕⊖⊖⊖
1,
2,
3
Very low |
|
Depression (Children’s Depression Inventory,
CDI) – 12-week follow-up period |
1 study (75 participants) | Mean 53.9 (SD 7.8) | Mean 44.1 (SD 8.7);
Mean difference -9.8 (95% KI -16.01 to -3.59) |
⊕⊖⊖⊖
1,
2,
3
Very low |
|
Anxiety (The Revised Children’s Manifest
Anxiety Scale, RCMAS) – 12-week follow-up period |
1 study (75 participants) | Mean 56.5 (SD 10.2) | Mean 39.6 (SD 10.6);
Mean difference -16.9 (95% KI -25.9 to -7.9) |
⊕⊖⊖⊖
1,
2,
3
Very low |
|
Post-traumatic stress (The Childhood
Posttraumatic Stress Reaction Index) – 12- week follow-up period |
1 study (75 participants) | Mean 17.8 (SD 9.1) | Mean 19.6 (SD 11.4);
Mean difference -16.9 (95% KI -5.67 to 9.27) |
⊕⊖⊖⊖
1,
2,
3
Very low |
|
Social adjustment (The Social Adjustment
Inventory for Children and Adolescents, SAICA). – 12-week follow-up period |
1 study (75 participants) | Mean 1.8 (SD 0.4) | Mean 1.6 (SD 0.2);
Mean difference -0.20 (95% KI -0.47 to 0.07) |
⊕⊖⊖⊖
1,
2,
3
Very low |
|
Parental depression (scale not reported)
– 12-week follow-up period |
1 study (75 participants) | Mean 9.7 (SD 4.5) | Mean 11.1 (SD 10.5);
Mean difference -1.40 (95% KI -3.53 to 6.33) |
⊕⊖⊖⊖
1,
2,
3
Very low |
| Adverse effects | Not reported | |||
1. Downgraded by 1 level due to risk of bias (no blinding).
2. Downgraded by 1 level due to imprecision (few participants).
3. Downgraded by 1 level due to imprecision (only 1 study).