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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Semin Cancer Biol. 2019 Aug 21;67(Pt 1):57–64. doi: 10.1016/j.semcancer.2019.08.027

Figure 3:

Figure 3:

Model of SOX4 role in cancer. TGFβ and Wnt activate PI3K/AKT to induce and stabilize SOX4 protein. SOX4 recruits β-catenin and interacts with SMAD3 at promoters of genes critical for EMT.