Table 1:
Cancer vs. Normal studies in the Oncomine database showing significant SOX4 changes in mRNA expression. SOX4 is upregulated in 107 of 462 unique studies across over 20 types of malignancies. In contrast, MYC was found upregulated in only 41 studies, as was SOX9. The SOX factor SOX3, which has little association with cancer, was upregulated in only two studies, and downregulated in three (not shown).
| Cancer Type | # Studies with SOX4 Upregulated |
# Studies with SOX4 Downregulated |
# Studies with MYC Upregulated |
# Studies with MYC Downregulated |
# Studies with SOX9 Upregulated |
# Studies with SOX9 Downregulated |
|---|---|---|---|---|---|---|
| Bladder | 4 | - | - | - | 1 | - |
| Brain | 10 | - | 7 | 1 | 5 | - |
| Breast | 1 | - | 1 | 10 | - | |
| Cervical | 4 | - | - | - | - | - |
| Colorectal | 13 | - | 20 | - | 17 | - |
| Esophageal | 6 | - | - | - | 2 | - |
| Gastric | 2 | - | - | - | 1 | - |
| Head & Neck | 8 | - | 2 | - | - | - |
| Kidney | 2 | 1 | 2 | - | 2 | - |
| Leukemia | 15 | 5 | - | 3 | - | - |
| Liver | 6 | - | - | 1 | 6 | - |
| Lung | 9 | - | - | - | 1 | - |
| Lymphoma | 1 | 2 | 2 | 2 | - | 1 |
| Melanoma | 1 | - | - | - | - | 1 |
| Myeloma | - | 1 | 1 | - | - | - |
| Other | 9 | - | 1 | 1 | - | 5 |
| Ovarian | - | - | - | - | 4 | - |
| Pancreatic | 3 | - | - | - | - | - |
| Prostate | 6 | - | 5 | - | - | - |
| Sarcoma | 8 | - | - | 4 | 2 | 1 |
| Significant Unique Analyses | 107 | 9 | 41 | 22 | 41 | 8 |
| Total Unique | 462 | 470 | 437 | |||