Fig. 4.

Paclitaxel preserves short- and long-term memory. The radial water tread (RWT) maze tests spatial learning and memory. Maze test was administered from Day 10 to 22 post-injury. A) Graph indicates learning/acquisition phase over Days 1–4, where saline-treated rmTBI mice did not learn the maze as compared to sham and PTX-treated rmTBI. Paclitaxel (PTX) rmTBI mice learned the maze similar to Sham. B) Paclitaxel subjects were significantly improved from saline in both short-term memory (Day 5) as well as long term memory (tested on Day 12).