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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Ann Biomed Eng. 2019 Jun 19;47(11):2213–2231. doi: 10.1007/s10439-019-02302-4

Figure 4.

Figure 4.

The mechanical strain and its exposure time mediated mRNA level of proinflammatory genes in peritoneal macrophages (A) and MIP-2 protein secretion in fetal lung cells (B). (A) The changes in iNOS, COX-2, IL-1β, MIP-1α, and MIP-2 mRNA level with prolonged 20% mechanical strain exposure. * indicated p<0.05, ** indicated p<0.01, *** indicated p<0.001 versus unstretched controls. Error bars represented standard deviation with n=3. (49) (B) MIP-2 production of rat macrophages over time. White columns indicate control, Black columns indicated mechanical loading of 5% and 40 cycles/min, Light grey indicated LPS stimulation, and Dark grey columns indicate mechanical loading of 5% and 40 cycles/min and LPS stimulation. * indicated p<0.05 versus control, ** indicated p<0.05 versus all other groups, # indicated p<0.05 versus the rest of the groups (104)