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Dose‐ (A) and time‐ (B) dependent effects of PKM‐833 on AEA concentrations in rat brain. (A) PKM‐833 (0.3‐3 mg/kg, p.o.) was administered 1 hour before decapitation. (B) PKM‐833 (1 mg/kg, p.o.) was administered from 1 to 48 hours before decapitation. Data are expressed as the mean ± SEM of three animals. Asterisks represent a significant difference between PKM‐833 treatment and vehicle groups, *P < .05, **P < .01, (Dunnett's test)
