| 1 Pruritus improvement |
1 |
15 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.23 [0.72, 2.10] |
| 2 Mean of worst itching scores over preceding 24 hours between randomisation and delivery |
1 |
111 |
Mean Difference (IV, Fixed, 95% CI) |
‐12.90 [‐22.59, ‐3.21] |
| 3 Mean of average itching scores over preceding 24 hours between randomisation and delivery |
1 |
111 |
Mean Difference (IV, Fixed, 95% CI) |
‐18.6 [‐27.52, ‐9.68] |
| 4 Stillbirth |
3 |
233 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.31 [0.03, 2.84] |
| 5 Fetal distress/asphyxial event |
5 |
304 |
Risk Ratio (M‐H, Random, 95% CI) |
0.67 [0.22, 2.02] |
| 6 Subgroup analysis ‐ fetal distress/asphyxial events |
1 |
94 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.71 [0.15, 3.40] |
| 6.1 Bile acid levels < 40 µmol/L |
1 |
71 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.15, 6.90] |
| 6.2 Bile acid levels ≥ 40 µmol/L |
1 |
23 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.31 [0.01, 6.85] |
| 7 Bile acid reduction, µmol/L |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 7.1 At 20 days |
1 |
16 |
Mean Difference (IV, Fixed, 95% CI) |
30.4 [23.32, 37.48] |
| 8 ALT, IU/L |
2 |
83 |
Mean Difference (IV, Random, 95% CI) |
‐109.00 [‐182.48, ‐39.51] |
| 8.1 At two weeks |
1 |
68 |
Mean Difference (IV, Random, 95% CI) |
‐90.21 [‐101.96, ‐78.46] |
| 8.2 At three weeks |
1 |
15 |
Mean Difference (IV, Random, 95% CI) |
‐175.0 [‐294.23, ‐55.77] |
| 9 ALT, IU/L |
1 |
16 |
Mean Difference (IV, Fixed, 95% CI) |
‐50.88 [‐75.14, ‐26.62] |
| 9.1 At 20 days |
1 |
16 |
Mean Difference (IV, Fixed, 95% CI) |
‐50.88 [‐75.14, ‐26.62] |
| 10 ALT reduction, IU/L |
1 |
16 |
Mean Difference (IV, Fixed, 95% CI) |
121.0 [100.93, 141.07] |
| 10.1 At 20 days |
1 |
16 |
Mean Difference (IV, Fixed, 95% CI) |
121.0 [100.93, 141.07] |
| 11 Caesarean section |
4 |
210 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.00 [0.82, 1.23] |
| 12 Postpartum haemorrhage |
2 |
127 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.77 [0.20, 2.98] |
| 13 Adverse effects |
3 |
220 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.32 [0.66, 2.63] |
| 14 Meconium‐stained liquor |
3 |
274 |
Risk Ratio (M‐H, Random, 95% CI) |
0.56 [0.24, 1.30] |
| 15 Mean gestational age at birth |
3 |
142 |
Mean Difference (IV, Random, 95% CI) |
2.68 [‐0.13, 5.48] |
| 16 Spontaneous birth at less than 37 weeks |
2 |
109 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.99 [0.41, 2.36] |
| 17 Total preterm birth at less than 37 weeks |
2 |
179 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.46 [0.28, 0.73] |
| 18 Admission to neonatal intensive care unit |
1 |
124 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.48 [0.18, 1.31] |
