Comparison 2. SAMe versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Stillbirth/neonatal death	1	18	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Bile acid reduction, µmol/L	1	16	Mean Difference (IV, Fixed, 95% CI)	17.5 [12.30, 22.70]
2.1 At 20 days	1	16	Mean Difference (IV, Fixed, 95% CI)	17.5 [12.30, 22.70]
3 ALT reduction, IU/L	1	16	Mean Difference (IV, Fixed, 95% CI)	139.6 [119.06, 160.14]
3.1 At 20 days	1	16	Mean Difference (IV, Fixed, 95% CI)	139.6 [119.06, 160.14]
4 Caesarean section	1	18	Risk Ratio (M‐H, Fixed, 95% CI)	1.14 [0.75, 1.74]
5 Spontaneous birth at less than 37 weeks	1	30	Risk Ratio (M‐H, Fixed, 95% CI)	0.4 [0.09, 1.75]
6 Total preterm birth at less than 37 weeks	1	18	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.45, 1.26]