Huang 2004.

Methods	Randomised controlled trial.
Participants	60 women randomised. Recruitment: July ‐ October 2002. Inclusion criteria: primigravidae, singleton pregnancies, pruritus in the second half of pregnancy, raised serum CG (> 10 UNL) and ALT. Exclusion criteria: PIH; gestational diabetes; anaemia; other liver (hepatitis A, B, C, D) and gallbladder diseases.
Interventions	YCHD (n = 35). BD orally for 3 weeks. SAMe (n = 25). IV infusion of 2 x 500 mg daily for 3 weeks. Pruritus, serum bile acids and LFTs were assessed after 3 weeks treatment.
Outcomes	Maternal: improvement in pruritus; serum CG; ALT; bilirubin; length of gestation; delivery by CS. Fetal/neonatal: mortality; Apgar score < 7; meconium‐stained liquor; preterm birth at < 37 weeks; birthweight; asphyxial events; umbilical cord artery pH, PO2, PCO2.
Notes	Full article in Chinese, abstract published in English.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random number table.
Allocation concealment (selection bias)	Unclear risk	Not stated.
Blinding (performance bias and detection bias) All outcomes	High risk	Not mentioned. Unlikely to be blinded because these 2 drugs have different modes of administration.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up.
Selective reporting (reporting bias)	Low risk	All the pre‐specified outcomes reported.
Other bias	High risk	Imbalance in numbers randomised to each group (35 versus 25) which may indicate a failure of proper randomisation.