Comparison 2. Rectal misoprostol versus no uterotonic/placebo (subgroups by dose).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Severe postpartum haemorrhage (>= 1000 mL)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 600 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.2 400 mcg	1	542	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.35, 1.37]
2 Use of additional uterotonics	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 600 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.2 400 mcg	1	546	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.31, 1.62]
3 Manual removal of placenta	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 600 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 400 mcg	1	546	Risk Ratio (M‐H, Fixed, 95% CI)	3.04 [0.12, 74.40]
4 Third stage >= 30 minutes	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 600 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.2 400 mcg	1	540	Risk Ratio (M‐H, Fixed, 95% CI)	0.51 [0.05, 5.56]
5 Vomiting	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 600 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.2 400 mcg	1	546	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.06, 16.14]
6 Abdominal pain	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 600 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6.2 400 mcg	1	546	Risk Ratio (M‐H, Fixed, 95% CI)	3.04 [0.12, 74.40]
7 Any shivering	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 600 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
7.2 400 mcg	1	70	Risk Ratio (M‐H, Fixed, 95% CI)	0.26 [0.03, 2.25]