Comparison 3. Sublingual misoprostol versus no uterotonic/placebo (subgroups by dose).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maternal death	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2 Severe postpartum haemorrhage (>= 1000 mL)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 600 mcg	1	661	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.45, 0.98]
2.2 400 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3 Postpartum haemorrhage (>= 500 mL)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 600 mcg	1	661	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.76, 1.04]
3.2 400 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Nausea	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 600 mcg	1	661	Risk Ratio (M‐H, Fixed, 95% CI)	0.50 [0.09, 2.72]
4.2 400 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Vomiting	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 600 mcg	1	661	Risk Ratio (M‐H, Fixed, 95% CI)	2.51 [0.79, 7.92]
5.2 400 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Diarrhoea	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 600 mcg	1	661	Risk Ratio (M‐H, Fixed, 95% CI)	2.51 [0.79, 7.92]
6.2 400 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
7 Any shivering	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 600 mcg	1	661	Risk Ratio (M‐H, Fixed, 95% CI)	2.43 [1.96, 3.01]
7.2 400 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
8 Pyrexia (>= 38 degrees C)	1	661	Risk Ratio (M‐H, Fixed, 95% CI)	7.11 [3.85, 13.12]
8.1 600 mcg	1	661	Risk Ratio (M‐H, Fixed, 95% CI)	7.11 [3.85, 13.12]
8.2 400 mcg	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]