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. 2012 Aug 15;2012(8):CD000494. doi: 10.1002/14651858.CD000494.pub4

Comparison 7. Sublingual misoprostol versus injectable uterotonic (subgroups by dose).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Severe postpartum haemorrhage (>= 1000 mL) 3 270 Risk Ratio (M‐H, Fixed, 95% CI) 0.54 [0.23, 1.27]
1.1 600 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.2 400 mcg 2 220 Risk Ratio (M‐H, Fixed, 95% CI) 0.6 [0.24, 1.53]
1.3 50 mcg 1 50 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.04, 2.99]
2 Postpartum haemorrhage (>= 500 mL) 6 663 Risk Ratio (M‐H, Fixed, 95% CI) 1.00 [0.83, 1.21]
2.1 600 mcg 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 2.0 [0.40, 10.11]
2.2 400 mcg 3 353 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.83, 1.17]
2.3 200 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.4 50 mcg 1 50 Risk Ratio (M‐H, Fixed, 95% CI) 0.88 [0.37, 2.05]
3 Blood loss (mL) 5   Mean Difference (IV, Fixed, 95% CI) Totals not selected
3.1 600 mcg 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
3.2 400 mcg 3   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
3.3 200 mcg 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
3.4 50 mcg 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
4 Use of additional uterotonics 7 1013 Risk Ratio (M‐H, Fixed, 95% CI) 0.61 [0.44, 0.85]
4.1 600 mcg 2 210 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.11, 1.02]
4.2 400 mcg 5 603 Risk Ratio (M‐H, Fixed, 95% CI) 0.63 [0.44, 0.90]
4.3 200 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 1.33 [0.31, 5.81]
5 Blood transfusion 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.1 600 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.2 400 mcg 1 120 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Postpartum haemoglobin 4 533 Mean Difference (IV, Fixed, 95% CI) ‐0.02 [‐0.25, 0.21]
6.1 600 mcg 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.2 400 mcg 3 333 Mean Difference (IV, Fixed, 95% CI) ‐0.06 [‐0.48, 0.36]
6.3 200 mcg 1 200 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐0.28, 0.28]
7 Manual removal of placenta 1 120 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.01, 8.02]
7.1 600 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.2 400 mcg 1 120 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.01, 8.02]
8 Duration of third stage (minutes) 2 500 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐0.22, 0.22]
8.1 600 mcg 1 150 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐0.32, 0.32]
8.2 400 mcg 1 150 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐0.32, 0.32]
8.3 200 mcg 1 200 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐1.39, 1.39]
9 Any side‐effect 1 100 Risk Ratio (M‐H, Fixed, 95% CI) 1.41 [0.87, 2.29]
9.1 400 mcg 1 100 Risk Ratio (M‐H, Fixed, 95% CI) 1.41 [0.87, 2.29]
10 Nausea 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
10.1 400 mcg 1 133 Risk Ratio (M‐H, Fixed, 95% CI) 6.09 [0.75, 49.22]
10.2 200 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 0.5 [0.22, 1.12]
11 Vomiting 4   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
11.1 600 mcg 0   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.2 400 mcg 2   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.3 50 mcg 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.4 200 mcg 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
12 Headache 2 300 Risk Ratio (M‐H, Fixed, 95% CI) 0.75 [0.37, 1.52]
12.1 600 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
12.2 400 mcg 1 100 Risk Ratio (M‐H, Fixed, 95% CI) 0.75 [0.28, 2.00]
12.3 200 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 0.75 [0.27, 2.08]
13 Abdominal pain 1 133 Risk Ratio (M‐H, Fixed, 95% CI) 5.07 [0.25, 103.73]
13.1 400 mcg 1 133 Risk Ratio (M‐H, Fixed, 95% CI) 5.07 [0.25, 103.73]
14 Diarrhoea 1 133 Risk Ratio (M‐H, Fixed, 95% CI) 3.04 [0.13, 73.42]
14.1 400 mcg 1 133 Risk Ratio (M‐H, Fixed, 95% CI) 3.04 [0.13, 73.42]
15 Any shivering 5 783 Risk Ratio (M‐H, Fixed, 95% CI) 9.06 [4.46, 18.39]
15.1 600 mcg 1 150 Risk Ratio (M‐H, Fixed, 95% CI) 27.0 [1.63, 446.10]
15.2 400 mcg 3 383 Risk Ratio (M‐H, Fixed, 95% CI) 7.53 [3.44, 16.49]
15.3 200 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 17.0 [0.99, 290.62]
15.4 50 mcg 1 50 Risk Ratio (M‐H, Fixed, 95% CI) 3.0 [0.13, 70.30]
16 Pyrexia >= 38 degrees C 4 653 Risk Ratio (M‐H, Fixed, 95% CI) 13.04 [4.77, 35.62]
16.1 600 mcg 1 150 Risk Ratio (M‐H, Fixed, 95% CI) 33.0 [2.02, 540.22]
16.2 400 mcg 4 503 Risk Ratio (M‐H, Fixed, 95% CI) 10.18 [3.45, 30.06]