Comparison 13. Intramuscular prostaglandin versus injectable uterotonics (subgroups by low‐ and high‐risk pregnancy).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Postpartum haemorrhage (>= 500 mL)	5	564	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.70, 1.61]
1.1 Low‐risk women	3	415	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.53, 2.37]
1.2 High‐risk women	2	149	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.62, 1.68]
2 Severe postpartum haemorrhage (>= 1000 mL)	2	119	Risk Ratio (M‐H, Fixed, 95% CI)	0.41 [0.14, 1.20]
2.1 Low‐risk women	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.06, 6.57]
2.2 High‐risk women	1	69	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.11, 1.23]
3 Blood loss (mL)	8		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.1 Low‐risk women	6		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 High‐risk women	2		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Use of additional uterotonics	4	422	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.28, 3.68]
4.1 Low‐risk women	4	422	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.28, 3.68]
4.2 High‐risk women	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Blood transfusion	2	129	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.39, 2.86]
5.1 Low‐risk women	1	60	Risk Ratio (M‐H, Fixed, 95% CI)	2.0 [0.40, 10.11]
5.2 High‐risk women	1	69	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.17, 2.53]
6 Manual removal of placenta	5	631	Risk Ratio (M‐H, Fixed, 95% CI)	1.09 [0.31, 3.81]
6.1 Low‐risk women	4	562	Risk Ratio (M‐H, Fixed, 95% CI)	3.22 [0.13, 77.34]
6.2 High‐risk women	1	69	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.20, 3.39]
7 Duration of third stage (minutes)	7		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
7.1 Low‐risk women	5		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
7.2 High‐risk women	2		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
8 Postpartum haemoglobin	1	215	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐0.27, 0.27]
8.1 Low‐risk women	1	215	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐0.27, 0.27]
8.2 High‐risk women	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
9 Any side‐effect	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
9.1 Low‐risk women	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
9.2 High‐risk women	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
10 Nausea	3	280	Risk Ratio (M‐H, Fixed, 95% CI)	2.39 [0.36, 16.09]
10.1 Low‐risk women	2	200	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.07, 16.55]
10.2 High‐risk women	1	80	Risk Ratio (M‐H, Fixed, 95% CI)	5.0 [0.25, 100.97]
11 Vomiting	3		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
11.1 Low‐risk women	3		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
11.2 High‐risk women	0		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
12 Headache	2	295	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.28, 3.57]
12.1 Low‐risk women	1	215	Risk Ratio (M‐H, Fixed, 95% CI)	0.20 [0.01, 4.08]
12.2 High‐risk women	1	80	Risk Ratio (M‐H, Fixed, 95% CI)	2.0 [0.39, 10.31]
13 Abdominal pain	3	331	Risk Ratio (M‐H, Fixed, 95% CI)	4.99 [1.46, 17.05]
13.1 Low‐risk women	2	262	Risk Ratio (M‐H, Fixed, 95% CI)	5.33 [1.40, 20.30]
13.2 High‐risk women	1	69	Risk Ratio (M‐H, Fixed, 95% CI)	3.26 [0.14, 77.46]
14 Diarrhoea	5	617	Risk Ratio (M‐H, Fixed, 95% CI)	12.28 [4.47, 33.70]
14.1 Low‐risk women	4	537	Risk Ratio (M‐H, Fixed, 95% CI)	11.88 [4.03, 35.03]
14.2 High‐risk women	1	80	Risk Ratio (M‐H, Fixed, 95% CI)	15.0 [0.89, 254.13]
15 Pyrexia (>= 38 degrees C)	1	112	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
15.1 Low‐risk women	1	112	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
15.2 High‐risk women	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]