Comparison 16. Drug/dose: misoprostol 600 mcg oral versus 400 mcg oral.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Postpartum haemorrhage (>= 500 mL)	1	397	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.62, 1.24]
2 Severe postpartum haemorrhage (>= 1000 mL)	2	797	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.50, 1.39]
3 Blood loss (mL)	2	547	Mean Difference (IV, Fixed, 95% CI)	‐30.00 [‐41.84, ‐18.16]
4 Use of additional uterotonics	3	947	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.66, 1.35]
5 Blood transfusion	2	797	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Manual removal of placenta	2	797	Risk Ratio (M‐H, Fixed, 95% CI)	1.22 [0.35, 4.20]
7 Duration of third stage (minutes)	2	547	Mean Difference (IV, Fixed, 95% CI)	‐0.04 [‐0.36, 0.27]
8 Third stage >= 30 minutes	1	400	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.31, 28.60]
9 Nausea	2	792	Risk Ratio (M‐H, Fixed, 95% CI)	1.65 [0.22, 12.48]
10 Vomiting	2	792	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.06, 15.88]
11 Headache	1	398	Risk Ratio (M‐H, Fixed, 95% CI)	1.5 [0.25, 8.88]
12 Abdominal pain	1	398	Risk Ratio (M‐H, Fixed, 95% CI)	1.5 [0.63, 3.59]
13 Diarrhoea	1	397	Risk Ratio (M‐H, Fixed, 95% CI)	8.96 [0.49, 165.23]
14 Shivering	3	945	Risk Ratio (M‐H, Fixed, 95% CI)	1.37 [1.12, 1.69]
15 Pyrexia (>= 38 degrees C)	3	944	Risk Ratio (M‐H, Fixed, 95% CI)	2.04 [1.45, 2.88]