| Methods |
Random allocation from a table of random numbers. No mention of blinding or placebo use. |
| Participants |
150 low‐risk women after vaginal delivery in Assiut, Egypt.
Excluded: labour < 2 hours, prolonged labour (> 24 hours), magnesium sulphate therapy during labour, history of postpartum haemorrhage, chorioamnionitis, multiple pregnancy, antepartum haemorrhage and episiotomy. |
| Interventions |
Carboprost trometamol* 0.250 mg IM vs methylergometrine maleate 0.2 mg IV. |
| Outcomes |
Blood loss, duration of third stage, side‐effects.
Measurement of blood loss: immediate blood loss was collected in trays and measured. Also, pads were used to collect blood for 4 hours and weighed. |
| Notes |
Management of third stage: reported as active but only uterotonic use is mentioned.
No mention of exclusions or missing data. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
"using a table of random numbers." |
| Allocation concealment (selection bias) |
High risk |
Inadequate concealment. |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
No mention of blinding or placebo use. |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
No mention of exclusions or missing data. |
| Selective reporting (reporting bias) |
Unclear risk |
Not all of the primary outcomes of the review were reported. |
| Other bias |
Low risk |
There were no significant differences between the 2 groups in age, parity and duration of gestation. |
