| Methods |
Randomly drawn envelopes containing the treatment codes. Placebos were not used. |
| Participants |
602 women after vaginal delivery in France.
Exclusion criteria: preterm birth (< 32 weeks), antepartum haemorrhage, intrauterine fetal death, uterine scar, caesarean section, multiple pregnancy, pre‐eclampsia. |
| Interventions |
Misoprostol 600 mcg orally vs oxytocin 2.5 IU IV given after cord clamp, vs no uterotonic. |
| Outcomes |
Blood loss, duration of third stage, side‐effects.
Blood loss was measured. |
| Notes |
Management of the third stage: active with immediate cord clamping. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
"randomly drawn envelopes." |
| Allocation concealment (selection bias) |
Low risk |
Used opaque envelopes. |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
No mention of blinding. |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
No mention of loss to follow‐up or exclusion after randomisation. |
| Selective reporting (reporting bias) |
Unclear risk |
Not all of the primary outcomes have been reported. |
| Other bias |
Low risk |
The characteristics of all the groups are comparable. |
