| Methods |
Randomisation by computer‐generated random‐number list, allocation concealment by opening sealed opaque envelopes. Unclear if outcome assessments were blinded. |
| Participants |
100 women undergoing caesarean section at the All India Institute of Medical Sciences, New Delhi, India. Women with risk factors for postpartum haemorrhage were not eligible. |
| Interventions |
Misoprostol 400 mcg sublingually vs 20 IU oxytocin in 1 litre lactated Ringer's solution at 125 mL/h. All women had spinal anaesthesia. |
| Outcomes |
Blood loss, side‐effects.
Blood loss measurement: volume of blood in the suction bottle + weighing of blood‐soaked linen. |
| Notes |
Management of the third stage: not applicable. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
"computer generated random number." |
| Allocation concealment (selection bias) |
Low risk |
"sealed opaque envelopes." |
| Blinding (performance bias and detection bias)
All outcomes |
High risk |
Open‐labeled. Unclear if outcome assessments were blinded. |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
There were no withdrawals following randomisation. |
| Selective reporting (reporting bias) |
Unclear risk |
Not all of the primary outcomes of the review were reported. |
| Other bias |
Low risk |
"There were no significant differences in demographic data in relation to age, parity, gestation, history of previous cesarean section and neonatal birth weight." |
