India 2006c.

Methods	Computer‐generated, random‐number schedule with a random block list. Random allocation by giving the next of a series of non‐distinguishable envelopes containing active or placebo tablets. Identical placebos were used. Outcome assessments were blinded.
Participants	1620 women delivering at home or primary care centre in 4 primary health centre areas of Belgaum District, Karnataka State, India. Women were delivered by ANMs who were trained in the trial procedures and the intervention. 2 sets of midwives were involved in the study. 18 at the beginning and 12 leaving and replaced by 7 new ANMs.
Interventions	Misoprostol 600 mcg orally vs identical placebos.
Outcomes	Blood loss, side‐effects. Blood loss measurement: A calibrated blood collection drape placed under the buttocks following delivery. Blood loss was measured after 1 hour and 2 hours.
Notes	Management of the third stage: the ANMs practised expectant management of the third stage of labour apart from the uterotonic in the intervention arm.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"computer generation randomization list with a random block size."
Allocation concealment (selection bias)	Low risk	"non‐distinguishable envelopes."
Blinding (performance bias and detection bias) All outcomes	Low risk	Double‐blind, placebo‐controlled. Outcome assessments were blinded.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No mention of loss to follow‐up or exclusion after randomisation.
Selective reporting (reporting bias)	Low risk	Primary outcomes of the review were reported.
Other bias	Low risk	"The two groups did not differ across any characteristics."