India 2008b.

Methods	Randomised controlled trial.
Participants	215 parturients who were at term(≥ 37 to < 41 weeks of gestation), with singleton pregnancy in cephalic presentation and vertex as presenting part, having haemoglobin concentration of at least 10g/dL. Parturients with active renal or hepatic disease, bronchial asthma, parity > 4 and bleeding disorders were excluded.
Interventions	Intramuscular carboprost tromethamine (0.5 mL containing125 mcg) versus intravenous methyl ergometrine (0.5 mL containing 200 mcg), both at the time of the delivery of the anterior shoulder.
Outcomes	Duration of third stage of labour, measured blood loss, side‐effects (hypertension and diarrhoea).
Notes	Active management of third stage labour. Amount of blood loss was quantified by noting the increment in weight of standardized tampons, which were placed high up in the vagina immediately after placental delivery.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Simple randomisation, using odd numbers for the control group and even numbers for the intervention group.
Allocation concealment (selection bias)	Unclear risk	Unclear how the allocation concealment was done.
Blinding (performance bias and detection bias) All outcomes	Low risk	Partial blinding. The patient was blinded to the kind of intervention but the clinician and outcome assessor knew. This could not be hidden as the clinician could tell which oxytocic was being given from the mode of administration‐ie intravenous for methyl ergometrine and intramuscular for carboprost
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up or postrandomisation exclusions are reported.
Selective reporting (reporting bias)	Unclear risk	Not all of the primary outcomes of the review were reported.
Other bias	Low risk	Both groups were similar with regard to age distribution, parity and gestational age.