India 2010.

Methods	Randomised controlled trial.
Participants	200 women with singleton pregnancies, spontaneous onset of labour at term and vertex position admitted in active phase of labour were included. Exclusion criteria included hypertension, cardiac disease, renal disease, gastrointestinal disorders, respiratory disease, endocrinal problems, coagulation disorder and sensitivity to prostaglandins.
Interventions	IM 125 mcg PGF2α versus IV 0.2 mg of methergin at the time of the delivery of the anterior shoulder.
Outcomes	The interval between injection and expulsion of the placenta, amount of blood loss, third stage complications, side‐effects and need for second injection of additional drug.
Notes	Active management of third stage of labour Blood loss was estimated by blood and blood clots collected in the kidney tray and adding the difference in the weight of the drapes before use and after delivery.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"using random tables."
Allocation concealment (selection bias)	Unclear risk	Unclear on how the allocation concealment was done.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unclear on the blinding.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No loss to follow‐up or postrandomisation exclusions were reported.
Selective reporting (reporting bias)	Unclear risk	Not all of the primary outcomes of the review were reported.
Other bias	Low risk	The 2 groups were well matched in terms of gravidity, parity and age.