Mexico 2009.

Methods	Randomis double‐blind study.
Participants	200 patients requiring caesarean section with single or multiple pregnancy and not presenting placenta previa, blood dyscrasia or myomatosis. Patients with obstetrical haemorrhage caused by uterine lacerations and those who did not want to participate in the study were excluded.
Interventions	Misoprostol (800 mcg) intravaginally versus placebo (Manogen‐sorbitol with aerosol) Both groups received oxytocin after the birth of the baby.
Outcomes	Hb and Hct levels before and after labour and the difference and side‐effects (pain, fever, shivers, nausea, vomiting, average systolic and diastolic blood pressure before and after caesarean section) were measured.
Notes	AMTSL not applicable, as the study includes caesarean sections. Measurement of blood loss was not mentioned.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Unclear how the sequence generation was done.
Allocation concealment (selection bias)	Unclear risk	Unclear how the allocation concealment was done.
Blinding (performance bias and detection bias) All outcomes	Low risk	Double‐blinded. The tablets were placed in 200 separate envelopes and assigned a number that was chosen randomly. The content of the envelopes were not revealed until the end of the study.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No loss to follow‐up and postrandomisation exclusions were reported.
Selective reporting (reporting bias)	Unclear risk	Not all of the primary outcomes of the review were reported.
Other bias	Unclear risk	Not clear on the comparability of the groups at the baseline.