Nigeria 2003.

Methods	Randomised double‐blind trial with identical looking double placebos. Randomisation schedule generated using random‐number tables. Allocation concealment achieved by using sealed opaque packets containing both active and the corresponding placebo medication.
Participants	496 low‐risk women having vaginal births in 2 hospitals in Delta State, Nigeria. Women undergoing caesarean section and who had other risk factors for haemorrhage were excluded.
Interventions	Misoprostol 600 mcg in powder form dissolved in 50 mL water per os vs oxytocin 10 IU IM at delivery of anterior shoulder.
Outcomes	Blood loss, postdelivery haemoglobin, side‐effects. Blood loss estimated by the clinicians.
Notes	Management of third stage: controlled cord traction, no other details. No loss to follow‐up or postrandomisation exclusions reported.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"random number‐generated tables."
Allocation concealment (selection bias)	Low risk	"opaque sealed packets containing a card indicating group allocation."
Blinding (performance bias and detection bias) All outcomes	Low risk	Double‐blinded.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No loss to follow‐up or postrandomisation exclusions reported.
Selective reporting (reporting bias)	Unclear risk	Not all of the primary outcomes of the review were reported.
Other bias	Low risk	There were no significant differences between 2 groups.