| Methods |
Random allocation according to a computer‐generated random sequence. Serially numbered, opaque test tubes. Outcome assessments were blinded. |
| Participants |
600 women after delivery at Coronation Hospital, Johannesburg, South Africa.
Exclusion criteria: no mention of exclusion criteria. |
| Interventions |
Misoprostol 600 mcg oral vs placebo. |
| Outcomes |
Shivering, pyrexia.
Measurement of blood loss: blood in bed pan measured, linen and sanitary towels weighed. |
| Notes |
Management of third stage: placenta removed by cord traction after firm contraction of uterus.
No exclusions after randomisation. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
"Computer‐generated random sequence." |
| Allocation concealment (selection bias) |
Low risk |
"Serially numbered, opaque test tubes." |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Double‐blinded. |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
There were no withdrawals after randomisation and all outcomes were analysed in the allocated group. |
| Selective reporting (reporting bias) |
Low risk |
Primary outcomes of the review were reported. |
| Other bias |
Low risk |
The 2 groups were well‐matched. |
