| Methods |
Random allocation using random‐number tables. Trial was double blinded. |
| Participants |
65 low‐risk women with vaginal births at Basel University Hospital, Basel, Switzerland.
Exclusion criteria: multiple pregnancy, pre‐eclampsia, previous postpartum haemorrhage or antepartum haemorrhage, caesarean delivery. |
| Interventions |
Misoprostol 600 mcg orally vs placebo. |
| Outcomes |
Blood loss, length of third stage, use of additional uterotonics, side‐effects, haematocrit values.
Measurement of blood loss: estimation by delivery physicians. |
| Notes |
Management of third stage: early cord clamping and cord traction. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
"random number‐generated tables." |
| Allocation concealment (selection bias) |
Low risk |
Adequate. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Double‐blinded. |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
No exclusions after randomisation. |
| Selective reporting (reporting bias) |
Unclear risk |
Not all of the primary outcomes of the review were reported. |
| Other bias |
Low risk |
2 groups were comparable in the baseline. |
