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. Author manuscript; available in PMC: 2020 Feb 26.
Published in final edited form as: Eur J Med Chem. 2018 Dec 28;164:471–498. doi: 10.1016/j.ejmech.2018.12.054

Figure 3.

Figure 3

Inhibition of NMDAR responses by 2-naphthoic acid derivatives. A. 7, B. 79h, C. 79i, D. 79j. NAMs described in Table 6 were tested for activity at various concentrations to determine inhibitory potency and the percentage of maximum inhibition. Compounds were tested on NMDA receptors containing GluN1a and the indicated GluN2 subunit expressed in Xenopus oocytes. After obtaining a steady state NMDAR response evoked by 10 μM L-glutamate and 10 μM glycine, test compounds were co-applied with agonists at various concentrations. Values (mean ± s.e.m.) represent the % response in the presence of the test compound compared to response in the presence of agonists alone.