Methods |
"Prospectively randomized" into three groups. |
Participants |
Head injured adults admitted to hospital who were comatose on admission or who lapsed into coma for six hours or more. |
Interventions |
Dexamethasone: initially 24mg IV per day, for a maximum of 7 days, tapering of for the last 5.
Dexamethasone: initially 16mg IV daily, for a maximum of 7 days, tapering off for the last 5.
Placebo.
|
Outcomes |
Glasgow Outcome Scale at 6 months.
Gastrointestinal bleeding.
Infections (signs of pneumonia, wound infection, urinary infection, blood culture, CSF culture). |
Notes |
|
Risk of bias |
Bias |
Authors' judgement |
Support for judgement |
Allocation concealment? |
Low risk |
Adequate |