CRASH 2005.

Methods	Stratified random allocation via central randomisation service or identical coded treatment packs.
Participants	Adults (16 or older) less than 8 hours after head trauma with GCS of 14 or less on admission to hospital.
Interventions	High dose methylprednisolone for 48 hours. 2g over 1 hour, then 0.4g per hour for 48 hours. Identical placebo.
Outcomes	Mortality and GOS at 6 months. Complications (admission to intensive care, gastrointestinal bleeding, infections, neurosurgical operation).
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	Adequate