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. Author manuscript; available in PMC: 2020 Feb 26.
Published in final edited form as: J Am Chem Soc. 2019 May 29;141(23):9365–9372. doi: 10.1021/jacs.9b03435

Figure 2.

Figure 2.

(A) DSC traces of serine bPNA(+) complexes with dT6C4T6DNA at 1:1 stoichiometry, as labeled, at 25 μM DNA and bPNA+; (SK2M)5 is complexed with dT10C4T10. The (SK2M)3 trace is highlighted in red. All experiments were carried out in DPBS pH 7.4. (B) (Top) Illustration of hexapeptide bPNA(+) hybridizing with dT6C4T6 DNA with T-domains shown as red lines. (Lower) Binding isotherms of FITC-labeled bPNA+ (blue line) and dT6C4T6. Isotherms acquired by fluorescence anisotropy (EK2M)3 and electrophoretic mobility shift assay (SK2M)3. DNA concentration is 50 nM with (EK2M)3 (○) and 10 nM with (SK2M)3 (·).