Methods |
Randomised double blind trial. |
Participants |
67 mothers, 74 infants at less than 34 weeks' gestation. |
Interventions |
Antenatal intramuscular injection of vitamin K1 10 mg given to women at less than 34 weeks' gestation between 4 and 96 hours before delivery. |
Outcomes |
Primary: IVH (grades I‐IV).
Secondary: mode of delivery, severity of respiratory illness, survival and incidence of patent ductus arteriosus. |
Notes |
Vitamin K1 and control groups were similar with respect to birthweight and gestational age. No adverse effects due to vitamin K in mothers or infants. Losses to follow up were not reported. |
Risk of bias |
Bias |
Authors' judgement |
Support for judgement |
Adequate sequence generation? |
Unclear risk |
Not reported. |
Allocation concealment? |
Unclear risk |
Not reported. |
Blinding?
All outcomes |
Unclear risk |
Placebo used. |
Incomplete outcome data addressed?
All outcomes |
Unclear risk |
Unclear. |
Free of selective reporting? |
Unclear risk |
Unclear. |
Free of other bias? |
Unclear risk |
Unclear. |