| Methods |
Randomised double blind trial. |
| Participants |
67 mothers, 74 infants at less than 34 weeks' gestation. |
| Interventions |
Antenatal intramuscular injection of vitamin K1 10 mg given to women at less than 34 weeks' gestation between 4 and 96 hours before delivery. |
| Outcomes |
Primary: IVH (grades I‐IV).
Secondary: mode of delivery, severity of respiratory illness, survival and incidence of patent ductus arteriosus. |
| Notes |
Vitamin K1 and control groups were similar with respect to birthweight and gestational age. No adverse effects due to vitamin K in mothers or infants. Losses to follow up were not reported. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
Not reported. |
| Allocation concealment? |
Unclear risk |
Not reported. |
| Blinding?
All outcomes |
Unclear risk |
Placebo used. |
| Incomplete outcome data addressed?
All outcomes |
Unclear risk |
Unclear. |
| Free of selective reporting? |
Unclear risk |
Unclear. |
| Free of other bias? |
Unclear risk |
Unclear. |
