. Author manuscript; available in PMC: 2020 Feb 26.

Published in final edited form as: Int J Pharm. 2018 Apr 20;545(1-2):113–116. doi: 10.1016/j.ijpharm.2018.04.040

Table 1.

Stability of D-NAC in various simulated gastric and intestinal fluids

	Simulated Gastric Fluids		Simulated Intestinal Fluids
*Time (hrs.)*	*USPGF*	*FaSSGF*	*USPSIF*	*FaSSIF*	*FeSSIF*
0	100±0.9	100±6.8	100±1.7	100±3	100±1.5
2	126.3±3.4	104.1±4.3	105±0.6	109.4±1.4	93.4±0.4
4	119±2.7	112.9±8.7	113.3±1.2	113.9±1.4	88±1.2
6	112±3.2	108±3.2	102.1±2.2	106.2±3.4	95.8±1.3

The data is presented as % Assay ± SD of D-NAC at 100 μg/m concentration

USPGF-United States Pharmacopeia Simulated Gastric Fluid, FaSSGF-Fasted State Simulated Gastric Fluid from Biorelevant.com;

USPSIF- United States Pharmacopeia Simulated Gastric Fluid, FaSSIF- Fasted State Simulated Intestinal Fluid from Biorelevant.com, FeSSIF-Fed State Simulated Intestinal Fluid from Biorelevant.com