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The diffusion method (red) detected functionally related genes statistically better than the non-weighted (blue) and weighted (green) shortest path length approaches, as shown in a histogram plot (A) and a kernel density estimation plot (B) (KS test: p diffusion vs non-weighted SPL = 2.7e-28, p diffusion vs weighted SPL = 2.8e-11, p non-weighted vs weighted SPL = 2.7e-10).
