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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Alcohol Clin Exp Res. 2020 Jan 9;44(2):567–578. doi: 10.1111/acer.14272

Figure 1. NLRP3 inflammasome inhibitor MCC950 reduces alcohol preference in female mice and consumption in both female and male mice.

Figure 1.

Mice were housed singly and received daily intraperitoneal injection of either the NLRP3 inflammasome inhibitor MCC950 (5mg/kg BW; diluted in 0.5% DMSO) or vehicle injection (1% DMSO in 0.9% saline). Two-bottle choice of water or alcohol in drinking water at increasing concentrations (3%, 6%, 9% and 12%) for four days each was provided ad libitum. Consumption was measured and mice were provided fresh water and alcohol daily. A-B) Dose of alcohol consumed at each concentration was normalized to mouse body weight for male and female mice. C-D) Alcohol preference was determined as a ratio of the volume of alcohol consumed to the total liquid volume consumed per day in male and female mice. E-F) Total fluid intake (water plus alcohol) was measured and normalized to body weight in male and female mice. n=6 mice/group. Two-way ANOVA with Bonferroni correction results are described in the text and Supplemental Table 1; error bars depict mean ± SEM.