Table 2. The pathways enriched for the mRNAs implicated in the competing endogenous RNA (ceRNA) regulatory network.
| Term | Count | P-value | Genes |
|---|---|---|---|
| hsa04510:Focal adhesion |
5 |
0.001561 |
COL4A2, COL4A1, CCND2, TNC, KDR |
| hsa04060:Cytokine-cytokine receptor interaction |
5 |
0.003707 |
CXCL1, CCL22, CXCL5, KDR, CXCL10 |
| hsa04062:Chemokine signaling pathway |
4 |
0.006217 |
CXCL1, CCL22, CXCL5, CXCL10 |
| hsa04512:ECM-receptor interaction |
3 |
0.006331 |
COL4A2, COL4A1, TNC |
| *hsa04940:Type I diabetes mellitus |
2 |
0.018766 |
CPE, HLA-B |
| *hsa05200:Pathways in cancer |
4 |
0.021608 |
COL4A2, COL4A1, PPARG, RUNX1T1 |
| hsa04623:Cytosolic DNA-sensing pathway |
2 |
0.023854 |
IL33, CXCL10 |
| hsa04270:Vascular smooth muscle contraction | 2 | 0.042772 | EDNRA, PRKG1 |
Note: “*” indicates the pathways overlapped with the keratoconus-correlated pathways searched from Comparative Toxicogenomics Database.