FIG 1.

Overview of potential protoring protein interactions. (A) ZipA, with its N-terminal transmembrane domain, unstructured linker domain, and C-terminal (CT) FtsZ-binding domain, is shown attached to an FtsZ protofilament undergoing subunit treadmilling. FtsZ has its own unstructured linker, shown as a green squiggle. FtsA, tethered to the cytoplasmic membrane with its C-terminal amphipathic helix and a putative linker domain (shown as an orange squiggle), forms oligomeric minirings (shown here) that, like ZipA, bind to treadmilling FtsZ protofilaments. The figure was created with Biorender. (B) An FtsA miniring on a lipid monolayer, shown as two tomographic slices from averaged negative-stain electron micrograph images. (Republished from Nature Communications [12].)