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. 2019 Dec 12;40(3):697–713. doi: 10.1161/ATVBAHA.119.313430

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© 2019 The Authors.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 1. — Selection of long noncoding RNA (lncRNA) candidates from RNA sequencing in stable vs unstable carotid plaque. A, Filtering strategy applied to derive a shortlist of 47 significantly dysregulated lncRNAs. Gene Ontology term enrichment analysis of (B) upregulated and (C) downregulated protein-coding genes. D, Heatmap showing differentially expressed lncRNAs within 4 patient samples (as row Z score of the Log2 [fragments per kilobase million (FPKM)+1]). E, Top 5 lncRNAs significantly upregulated and downregulated from candidate panel. FC indicates fold change.