Table 2.

Potential adverse events of drugs used for latent tuberculosis infection (LTBI) treatment

Drug	Potential adverse effects	Comments
Isoniazid	Elevation of aminotransferases Symptomatic hepatitis Peripheral neuropathy	Close follow-up and caution in patients with baseline liver disease
Rifamycins (includes rifampin,rifapentine, and rifabutin)	Cutaneous rash Hematologic abnormalities Flu-like illness Elevation of aminotransferases Symptomatic hepatitis Orange discoloration of body fluids	Consider multiple potential drug-drug interactions (i.e., warfarin, anticonvulsants, opioids, antiretrovirals) Isoniazid-rifapentine not recommended in pregnant women or women expecting to be pregnant during treatment Isoniazid-rifapentine not recommended for children < 2 years of age