Table 3.

Effect of myricitrin and its SLN on GFR, urine glucose, plasma and urine level of BUN, Cr and, Alb

Groups	Plasma BUN (mg/dl)	Plasma Cr (mg/dl)	Plasma Alb (g/dl)	GFR (ml/min)
Control	42.43±0.68	0.241±0.005	3.11±0.05	95.34±6.42
Vehicle	42.20±0.65***	0.261±0.005***	3.12±0.06***	84.04±7.99**
Diabetes	58.67±0.71###	0.322±0.008###	2.64±0.03###	68.25±2.14###
Diabetes + myricitrin 1 mg/kg	54.02±0.43###**	0.297±0.006###*	2.73±0.01###	79.68±4.01#*
Diabetes + myricitrin 3 mg/kg	47.71±0.97##***	0.292±0.008###*	2.78±0.04###*	81.11±2.99*
Diabetes + myricitrin 10 mg/kg	45.80±1.22#***	0.341±0.004###	2.71±0.05###	51.03±2.02###*
Diabetes + myricitrin SLNs 1 mg/kg	48.08±1.60##***	0.252±0.013***	2.63±0.03###	83.08±4.30*
Diabetes + myricitrin SLNs 3 mg/kg	40.82±0.88***	0.233±0.008***	2.78±0.04###*	98.85±5.95***
Diabetes + myricitrin SLNs 10 mg/kg	39.43±0.32***	0.310±0.004###	2.75±0.04###	53.95±2.66###*

Data are presented as mean±SEM; n=12; #P<0.05, ##P<0.01 and ###P<0.001 compared to the control, *P<0.05, **P<0.01, and ***P<0.001 compared to the diabetes group. SLN: Solid lipid nanoparticle, GFR: Glomerular filtration rate, Cr: Creatinine, BUN: Blood urea nitrogen, Alb: Albumin