Table 3.
Groups |
Plasma BUN
(mg/dl) |
Plasma Cr
(mg/dl) |
Plasma Alb
(g/dl) |
GFR
(ml/min) |
---|---|---|---|---|
Control | 42.43±0.68 | 0.241±0.005 | 3.11±0.05 | 95.34±6.42 |
Vehicle | 42.20±0.65*** | 0.261±0.005*** | 3.12±0.06*** | 84.04±7.99** |
Diabetes | 58.67±0.71### | 0.322±0.008### | 2.64±0.03### | 68.25±2.14### |
Diabetes + myricitrin 1 mg/kg | 54.02±0.43###** | 0.297±0.006###* | 2.73±0.01### | 79.68±4.01#* |
Diabetes + myricitrin 3 mg/kg | 47.71±0.97##*** | 0.292±0.008###* | 2.78±0.04###* | 81.11±2.99* |
Diabetes + myricitrin 10 mg/kg | 45.80±1.22#*** | 0.341±0.004### | 2.71±0.05### | 51.03±2.02###* |
Diabetes + myricitrin SLNs 1 mg/kg | 48.08±1.60##*** | 0.252±0.013*** | 2.63±0.03### | 83.08±4.30* |
Diabetes + myricitrin SLNs 3 mg/kg | 40.82±0.88*** | 0.233±0.008*** | 2.78±0.04###* | 98.85±5.95*** |
Diabetes + myricitrin SLNs 10 mg/kg | 39.43±0.32*** | 0.310±0.004### | 2.75±0.04### | 53.95±2.66###* |
Data are presented as mean±SEM; n=12; #P<0.05, ##P<0.01 and ###P<0.001 compared to the control, *P<0.05, **P<0.01, and ***P<0.001 compared to the diabetes group. SLN: Solid lipid nanoparticle, GFR: Glomerular filtration rate, Cr: Creatinine, BUN: Blood urea nitrogen, Alb: Albumin