Table 4.
Groups |
Plasma Na
(mEq/l) |
Plasma K
(mEq/l) |
Urine Na
(mEq/l) |
Urine K
(mEq/l) |
FE Na
(%) |
FE K
(%) |
---|---|---|---|---|---|---|
Control | 171.25±1.65 | 5.52±0.28 | 136.33±11.86 | 75.50±5.90 | 0.525±0.016 | 9.54±1.07 |
Vehicle | 170.40±2.63 | 5.28±0.37 | 138.50±12.58** | 71.66±6.98** | 0.602±0.100*** | 10.09±1.98*** |
Diabetes | 173.33±2.02 | 5.10±0.28 | 185.33±12.97## | 105.50±9.13## | 1.277±0.138### | 24.60±1.10### |
Diabetes + myricitrin 1 mg/kg | 174.00±1.68 | 5.25±0.12 | 170.50±10.50# | 87.33±5.84* | 0.847±0.023#** | 14.38±0.89#*** |
Diabetes + myricitrin 3 mg/kg | 173.66±6.76 | 5.10±0.23 | 136.33±7.02** | 85.50±6.78* | 0.687±0.100*** | 14.62±2.5#*** |
Diabetes + myricitrin 10 mg/kg | 168.50±1.04 | 5.25±0.11 | 139.33±15.50** | 70.25±2.21*** | 1.104±0.098### | 17.87±0.83##** |
Diabetes + myricitrin SLNs 1 mg/kg | 180.25±5.75 | 5.55±0.17 | 166.33±10.96# | 82.50±4.52* | 0.720±0.069*** | 11.63±1.60*** |
Diabetes + myricitrin SLNs 3 mg/kg | 171.75±3.37 | 5.70±0.10 | 125.33±6.17** | 79.25±6.15** | 0.535±0.045*** | 10.02±1.05*** |
Diabetes + myricitrin SLNs 10 mg/kg | 169.25±3.94 | 5.47±0.08 | 135.50±13.02** | 69.00±4.72*** | 0.961±0.100##* | 15.18±1.70##*** |
Data are presented as mean±SEM; n=12; #P<0.05, ##P<0.01 and ###P<0.001 compared to the control, *P<0.05, **P<0.01, and ***P<0.001 compared to the diabetes group. SLN: Solid lipid nanoparticle, FE Na: Fractional excretion of sodium, FE K: Fractional excretion of potassium, NF-κB: Nuclear factor kappa B, TGF-β: Transforming growth factor-β