Table1.

Candidate genes involved in etiology of polycystic ovary syndrome related to obesity and dyslipidemia

Gene	Genetic marker(s)	Type of study	Physiologic function	Studied population	Type of polymorphism	References
ADIPOQ	T45G G276T	Meta-analysis	Glucose regulation and fatty acid oxidation	Different population	G276T	(29)
ADIPOQ	rs2241766 rs1501299	Family-based analysis	Glucose regulation and fatty acid oxidation	Chinese Han	rs1501299	(30)
ADIPOQ	SNPs at position −11377 of the ADIPOQ gene	Case-control	Glucose regulation and fatty acid oxidation	Japanese	ND	(31)
ADIPOQ	45T/G 276G/T	Meta-analysis	Glucose regulation and fatty acid oxidation	Different population	45T/G 276G/T	(32)
ADIPOQ	C45G15G(T/G) C276(G/T)	Case-control	Glucose regulation and fatty acid oxidation	Chinese Han	+45G15G(T/G) +276(G/T)	(33)
ADIPOQ	+45G15G(T/G) +276(G/T)	Case-control	Glucose regulation and fatty acid oxidation	Korean	+276(G/T)	(34)
FTO	rs9939609	Case-control	Energy homeostasis regulation	British/Irish	rs9939609	(35)
FTO	Five SNPs	Family-based and case-control	Energy homeostasis regulation	White American	rs1421085	(36)
FTO	rs9939609	Case-control	Energy homeostasis regulation	Australian	rs9939609	(37)
FTO	rs1421085 rs17817449 rs8050136	Case-control	Energy homeostasis regulation	Korean	rs1421085 rs17817449 rs8050136	(38)
MC4R	rs17782313 (T/C)	Case-control	Regulator of melanocortin neuronal pathways	Chinese	rs17782313	(39)
MC4R	rs12970134	Case-control	Regulator of melanocortin neuronal pathways	Czech	rs12970134	(40)
ADIPOQ	rs2241766	Case-control	Metabolic features of PCOS	Iranian	rs2241766 “TT”	(41)
SREBP-2 LXRa	rs2228314 rs11039155	Case-control	Lipid metabolism	Chinese Han	rs2228314 G to C rs11039155 G to A	(28)

ADIPOQ: Adiponectin; FTO: Fat mass, and obesity-associated; MC4R: Melanocortin 4 receptor; SREBP-2: Sterol Regulatory Element Binding Protein-2; LXRa: Liver X Receptor a; ND: No data