Table 1:
Patient Demographics and Tumor Characteristics
| Patient Demographics (n=50) | |
|---|---|
| Age at Biopsy of cSCC of interest | |
| Mean (SD) | 73.1 (10.5) |
| Gender | |
| Female | 14 (28.0%) |
| Male | 36 (72.0%) |
| Race | |
| Caucasian | 49 (100%) |
| Missing | 1 |
| Fitzpatrick skin type | |
| I | 1 (4.3%) |
| II | 18 (78.3%) |
| III | 4 (17.4%) |
| Missing | 27 |
| Immunosuppressed and History of Skin Cancer | |
| Immunosuppressed | 14 (28.6%) |
| History of Skin Cancer | 45 (90.0%) |
| Reason for Immunosuppression (One or Multiple) | |
| Organ Transplant | 9 (64.3%) |
| Chronic Lymphocytic leukemia | 3 (21.4%) |
| Inflammatory Disease | 2 (14.3%) |
| Tumor Characteristics of Primary Tumors for High and Low INPP5A Expression | ||||
|---|---|---|---|---|
| Brigham and Women’s Hospital T-Staging | ||||
| High INPP5A (n=41) | Low INPP5A (n=11) | Total (n=52) | P-value | |
| T0 | 5 (12.2%) | 0 (0.0%) | 5 (9.6%) | |
| T1 | 15 (36.6%) | 2 (18.2%) | 17 (32.7%) | |
| T2a | 13 (31.7%) | 2 (18.2%) | 15 (28.8%) | 0.06451 |
| T2b | 7 (17.1%) | 5 (45.5%) | 12 (23.1%) | |
| T3 | 1 (2.4%) | 2 (18.2%) | 3 (5.8%) | |
| Primary Tumor Diameter (cm) | ||||
| High INPP5A (n=40) | Low INPP5A (n=11) | Total (n=51) | P-value | |
| Mean (SD) | 2.2 (1.9) | 2.5 (2.1) | 2.3 (1.9) | 0.41552 |
| Primary Tumor Depth of Invasion | ||||
| High INPP5A (n=41) | Low INPP5A (n=11) | Total (n=52) | P-value | |
| In Situ | 5 (41.7%) | 0 (0.0%) | 5 (27.8%) | |
| Dermis/Subcutaneous Fat | 5 (41.7%) | 3 (50.0%) | 8 (44.4%) | 0.14081 |
| Cartilage/Muscle | 2 (16.7%) | 3 (50.0%) | 5 (27.8%) | |
| Primary Tumor Depth (mm) | ||||
| High INPP5A (n=21) | Low INPP5A (n=9) | Total (n=30) | P-value | |
| Mean (SD) | 3.7 (2.8) | 5.8 (3.1) | 4.3 (3.0) | 0.04152 |
| Primary Tumor Differentiation | ||||
| High INPP5A (n=41) | Low INPP5A (n=11) | Total (n=52) | P-value | |
| Well | 9 (28.1%) | 0 (0.0%) | 9 (22.0%) | |
| Moderate | 15 (46.9%) | 3 (33.3%) | 18 (43.9%) | 0.05211 |
| Poor | 8 (25.0%) | 6 (66.7%) | 14(34.1%) | |
| Perineural Invasion | ||||
| High INPP5A (n=41) | Low INPP5A (n=11) | Total (n=52) | P-value | |
| Perineural Invasion | 3 (8.8%) | 4 (44.4%) | 7 (16.3%) | 0.02571 |
| Tumor Characteristics: Local Recurrence, Metastasis, and Both | |||||
|---|---|---|---|---|---|
| Brigham and Women’s Hospital T-Staging | |||||
| Local Recurrence (n=20) | Metastasis (n=29) | Both (n=3) | Total (n=52) | P-Value | |
| T0 | 5 (25.0%) | 0 (0.0%) | 0 (0.0%) | 5 (9.6%) | |
| T1 | 12 (60.0%) | 4 (13.8%) | 1 (33.3%) | 17 (32.7%) | |
| T2a | 1 (5.0%) | 13 (44.8%) | 1 (33.3%) | 15 (28.8%) | 0.00011 |
| T2b | 2 (10.0%) | 9 (31.0%) | 1 (33.3%) | 12 (23.1%) | |
| T3 | 0 (0.0%) | 3 (10.3%) | 0 (0.0%) | 3 (5.8%) | |
| Primary tumor diameter (cm) | |||||
| Local Recurrence (n=19) | Metastasis (n=29) | Both (n=3) | Total (n=51) | P-Value | |
| Mean (SD) | 1.6 (1.5) | 2.7 (2.1) | 2.2 (1.1) | 2.3 (1.9) | 0.00853 |
| Primary Tumor Depth of Invasion | |||||
| Local Recurrence (n=5) | Metastasis (n=12) | Both (n=l) | Total (n=18) | ||
| In Situ | 5 (100.0%) | 0 (0.0%) | 0 (0.0%) | 5 (27.8%) | |
| Dermis / Subcutaneous Fat | 0 (0.0%) | 7 (58.3%) | 1 (100.0%) | 8 (44.4%) | |
| Cartilage / Muscle | 0 (0.0%) | 5 (41.7%) | 0 (0.0%) | 5 (27.8%) | |
| Primary Tumor Depth (mm) | |||||
| Local Recurrence (n=2) | Metastasis (n=26) | Both (n=2) | Total (n=30) | P-Value | |
| Mean (SD) | 2.9 (1.6) | 4.4 (3.1) | 5.4 (4.0) | 4.3 (3.0) | 0.70903 |
| Primary Tumor Differentiation | |||||
| Local Recurrence (n=10) | Metastasis (n=29) | Both (n=2) | Total (n=41) | P-Value | |
| Well | 8 (80.0%) | 1 (3.4%) | 0 (0.0%) | 9 (22.0%) | |
| Moderate | 0 (0.0%) | 17 (58.6%) | 1 (50.0%) | 18 (43.9%) | <0.00011 |
| Poor | 2 (20.0%) | 11 (37.9%) | 1 (50.0%) | 14 (34.1%) | |
| Perineural Invasion | |||||
| Local Recurrence (n=17) | Metastasis (n=24) | Both (n=2) | Total (n=43) | P-Value | |
| Perineural Invasion | 0 (0.0%) | 7 (29.2%) | 0 (0.0%) | 7 (16.3%) | 0.06221 |
1
Fisher’s Exact,
2
Wilcoxon Rank-Sum,
3
Kruskal Wallis,
INPP5A: inositol polyphosphate-5-phosphatase