Table 1. Data obtainable from various sequencing experiments.

	Whole genome sequencing	Whole exome sequencing	Targeted sequencing
Drivers	Substitutions and indels Structural variation including gene fusions	Substitutions and indels	Substitutions and indels limited to specific genes on panel
Copy number drivers (amplifications & homozygous deletions)	Comprehensive	Semi-reliable	Limited to genes on panel and not always reliable
Mutational signatures	Comprehensive	Limited	Not reliable
Complex rearrangements	Comprehensive	Not reliable	Not detectable
Copy number aberrations	Comprehensive	Semi-reliable	Not detectable
Germline variation	Comprehensive	High-penetrance allelles	Limited
Phylogenetic trees	Possible. Limited branching unless very high-depth	Possible	Limited