Figure 2.
Post-CCl4 peri-injury hepatocytes do not express Wnt targets GS and Glt1, but are positive for Tbx3. (A-D) Expression of GS in uninjured (A) and post-injury (B-D) liver. Rare GS+ hepatocytes are observed during injury repair (C, arrowhead). (E-H) Expression of Glt1 in uninjured (E) and post-injury (B-D) liver. (I-L) Expression of Tbx3 in uninjured (I) and post-injury (J-L) liver. Low levels of Tbx3 expression are induced in peri-injury hepatocytes as early as 3 days following injury (J, arrowheads). 100μm scale bars. Dashed line represents injury border. CV = central vein, PV = portal vein. Representative images from n=3 animals per timepoint.