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. 2019 Nov 19;50(3):250–263. doi: 10.4070/kcj.2019.0107

Figure 6. SMAD7 was the target gene of miR-484. (A) The expression of SMAD7 in ischemic myocardial tissue. (B) The correlation analysis of SMAD7 and miR-484. (C) The expression of SMAD7 mRNA in myocardial tissue. (D) The expression of miR-484 in myocardial cells transfected with miR-484 agomir and antagomir. (E) The expression of SMAD7 in myocardial cells transfected with miR-484 agomir and antagomir. (F) Target Scan predicted the target site for binding of SMAD7 to miR-484. (G) The dual luciferase reporter gene activity assay. (H) RNA immunoprecipitation analysis.

Figure 6

IgG = immunoglobulin G; mRNA = messenger RNA; MT = mutant; NC = negative control; SMAD7 = SMAD family member 7; WT = wild type.

*p<0.05 compared with Con group; †p<0.05 compared with IR group; ‡p<0.05 compared with IR-C group; §p<0.05 compared to the NC-mimics group; ∥p<0.05 compared with the anti-IgG group.