Table 3. Adverse events summary.
| Variable | Pioglitazone (n=69) | Glimepiride (n=66) | P value |
|---|---|---|---|
| Adverse eventa | 64 (92.8) | 58 (87.9) | 0.504 |
| Hypoglycemia | 3 (4.4) | 16 (24.2) | 0.002 |
| Upper respiratory infection | 10 (14.5) | 6 (9.1) | 0.481 |
| Dizziness | 5 (7.3) | 5 (7.6) | 1.000 |
| Headache | 3 (4.4) | 2 (3.0) | 1.000 |
| Weight gain | 4 (5.8) | 0 | 0.120 |
| Dyspepsia | 0 | 4 (6.1) | 0.055 |
| Acute diarrhea | 2 (2.9) | 1 (1.5) | 1.000 |
| Itching | 3 (4.4) | 0 | 0.245 |
| Edema | 3 (4.4) | 0 | 0.245 |
| Abdominal pain | 2 (2.9) | 0 | 0.497 |
| Ache | 2 (2.9) | 0 | 0.497 |
| Myalgia | 2 (2.9) | 0 | 0.497 |
| Palpitation | 0 | 2 (3.0) | 0.237 |
| Serious adverse event | 3 (4.4) | 0 | 0.245 |
| Fractureb | 2 (2.9) | 0 | 1.000 |
| Acute pyelonephritis | 1 (1.5) | 0 | 1.000 |
| Adverse drug reaction | 8 (11.6) | 23 (34.9) | 0.003 |
| Hypoglycemia | 1 (1.5) | 14 (21.2) | 0.001 |
| Dizziness | 1 (1.5) | 3 (4.6) | 0.358 |
| Weight gain | 2 (2.9) | 0 | 0.497 |
| Edema | 2 (2.9) | 0 | 0.497 |
Values are presented as number (%).
aOccurring in frequencies of ≥2% in either treatment group, bFractures of cuneiform bone of foot and intertrochanteric section of femur after falling.