Table 1. Comparison of epidemiological, surgical, and histological characteristics of patients with II stage endometrial cancer in relation to uterine risk group, postoperative external beam radiation and LN resection.
| Variables | All stage II | Stage II divided according to uterine risk group | LN resection | EBRT | ||||
|---|---|---|---|---|---|---|---|---|
| Low-risk | Intermediate-risk | High-risk | −LN | +LN | −RT | +RT | ||
| Number | 461 | 158 | 208 | 95 | 248 | 213 | 344 | 117 |
| Age (yr) | 68.0±10.9 | 64.6±11.6 | 69.2*±10.3 | 70.9*±9.5 | 68.8±11.3 | 67.0±10.3 | 69.2±11.3 | 64.4*±8.82 |
| ASA | 1.77±0.68 | 1.60±0.7 | 1.81†±0.66 | 1.95*±0.66 | 1.79±0.72 | 1.74±0.62 | 1.85±0.69 | 1.52*±0.58 |
| BMI | 27.8±6.29 | 27.6±6.9 | 28.4±5.9 | 27.0±6.0 | 27.4±6.28 | 28.3±6.29 | 27.9±6.26 | 27.6±6.4 |
| Grade 1 | 213 (46.2) | 107 (67.7) | 106§ (51.0) | - | 127 (51.2) | 86§ (40.4) | 167 (48.6) | 46‡ (39.3) |
| Grade 2 | 138 (29.9) | 51 (32.3) | 87 (41.8) | - | 82 (33.1) | 56 (26.3) | 90 (26.2) | 48 (41.0) |
| Grade 3 | 50 (10.8) | - | 15 (7.2) | 35§ (36.8) | 15 (6.1) | 35 (16.4) | 43 (12.5) | 7 (6.0) |
| Serous, clear, undiff. | 60 (13.0) | - | - | 60 (63.2) | 24 (9.7) | 36 (16.9) | 44 (12.8) | 16 (13.7) |
| Deep myometrial invasion | 255 (55.3) | 0 | 193* (92.8) | 62* (65.3) | 130 (52.4) | 125 (58.7) | 200 (58.1) | 55* (47.0) |
| Cervical glandular involvement | 175 (38.0) | 41 (26.0) | 74† (35.6) | 60* (63.2) | 90 (36.3) | 85 (39.9) | 133 (38.7) | 42 (35.9) |
| Endometrioid | 401 (87.0) | 158 (100) | 208 (100) | 35* (36.8) | 224 (90.3) | 177† (83.1) | 300 (87.2) | 101 (86.3) |
| Non-endometrioid | 60 (13.0) | - | - | 60 (63.2) | 24 (9.7) | 36 (16.9) | 44 (12.8) | 16 (13.7) |
| LVSI of know status | 94/299 (31.4) | 9/87 (10.3) | 62/153§ (40.5) | 23/59§ (39.0) | 49/152 (32.2) | 45/147 (30.6) | 69/229 (30.1) | 25/70 (35.7) |
| Unknown LVSI | 162 (35.1) | 71 (44.9) | 55 (26.4) | 36 (37.9) | 96 (38.7) | 66 (31.0) | 115 (33.4) | 47 (40.2) |
| Simple hysterectomy | 363 (78.7) | 127 (80.4) | 172 (86.7) | 64† (67.4) | 236 (95.2) | 127§ (59.6) | 256 (74.4) | 107§ (91.5) |
| Radical hysterectomy | 73 (15.8) | 20 (12.7) | 25 (12.0) | 28 (29.5) | 4 (1.6) | 69 (32.4) | 65 (18.9) | 8 (6.8) |
| Unknown | 25 (5.4) | 11 (7.0) | 11 (5.3) | 3 (3.2) | 8 (3.2) | 17 (8.0) | 23 (6.7) | 2 (1.7) |
| Nodal staging | 213 (46.2) | 56 (35.4) | 96* (46.1) | 61* (64.2) | 0 | 213* (100) | 192 (55.8) | 21* (18.0) |
| Pelvic LN resection | 213 (46.2) | 56 (35.4) | 96 (46.1) | 61 (64.2) | 0 | 213* (100) | 192 (55.8) | 21* (18.0) |
| Paraaortic LN resection | 11 (2.4) | 1 (0.6) | 4 (1.9) | 6 (6.3) | 0 | 11 (5.2) | 11 (3.2) | 0 |
| No adjuvant therapy | 296 (64.2) | 100 (63.3) | 138 (66.4) | 58§ (61.1) | 125 (50.4) | 171§ (80.3) | 296 (86.1) | 0§ |
| RT | 115 (25.0) | 47 (29.8) | 49 (23.6) | 19 (20.0) | 94 (37.9) | 21* (9.9) | - | 115 (98.3) |
| Chemo | 48 (10.4) | 10 (6.3) | 20 (9.6) | 18 (19.0) | 27 (10.9) | 21 (9.9) | 48 (14.0) | 0* |
| RT+Chemo | 2 (0.43) | 1 (0.6) | 1 (0.5) | - | 2 (0.8) | - | - | 2 (1.7) |
| Death <5 years | 120 (26.0) | 13 (8.2) | 63* (30.3) | 44* (46.3) | 75 (30.2) | 45† (21.1) | 97 (28.2) | 23 (19.7) |
| From cancer | 69 (15.0) | 6 (3.8) | 34* (16.4) | 29* (30.5) | 41 (16.5) | 28 (13.2) | 50 (14.5) | 19 (16.2) |
| From others | 51 (11.0) | 7 (4.4) | 29† (13.9) | 15† (15.8) | 34 (13.7) | 17 (8.0) | 47 (13.7) | 4† (3.4) |
Data are shown as mean±standard deviation or number (%).
ASA, American Society of Anesthesiologists; BMI, body mass index; EBRT, external beam radiotherapy; LN, lymph node; LVSI, lymphovascular space invasion; RT, radiation therapy; Undiff., undifferentiated.
*p<0.001, †p<0.05 using Student's t-test or χ2 test when intermediate-risk and high-risk were compared to low-risk or RT against no RT or LN resection against no LN resection; ‡p<0.001, §p<0.05 using χ2 test distribution when intermediate-risk and high-risk were compared to low-risk or between RT and no RT or LN resection and no LN resection.