Table 2. Predictors of 5-year survival or recurrence of stage II endometrial cancer were calculated for prognostic factors (uterine risk group, LVSI status, and LN status) and for treatments factors (type of hysterectomy, LN resection, postoperative EBRT, and chemotherapy) by univariate and multivariate Cox analysis.
| Variables | Overall survival | Cancer-specific survival | Progression-free survival | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. (%) | % (95% CI) | HR/aHR (95% CI) | % (95% CI) | HR/aHR (95% CI) | % (95% CI) | HR/aHR (95% CI) | |||
| Prognostic factors* | 461 | 73.9 (69.6–77.7) | 84.1 (80.3–87.2) | 76.3 (72.1–80.0) | |||||
| Uterine risk group | |||||||||
| Low-risk | 158 | 91.8 (86.3–95.1) | 96.2 (91.6–98.3) | 90.5 (84.7–94.1) | |||||
| Intermediate-risk | 208 | 69.6 (62.9–75.4) | 4.17‡/3.60‡ (1.95–6.65) | 82.2 (75.9–86.9) | 4.87‡/4.09§ (1.68–9.98) | 73.0 (66.1–78.6) | 3.02‡/2.63§ (1.44–4.79) | ||
| High-risk | 95 | 53.2 (42.6–62.7) | 7.89‡/6.82‡ (3.56–13.07) | 66.1 (54.9–75.1) | 11.26‡/10.41‡ (4.15–26.11) | 58.3 (47.2–67.8) | 5.51‡/5.08‡ (2.68–9.65) | ||
| No LVSI | 205 | 77.6 (71.2–82.7) | 87.2 (81.6–91.1) | 82.0 (75.9–86.7) | |||||
| LVSI | 94 | 62.8 (52.2–71.7) | 1.94§/1.47 (0.94–2.30) | 72.2 (61.4–80.5) | 2.46§/1.84‡ (1.04–3.26) | 62.9 (52.0–72.1) | 2.41‡/1.93§ (1.19–3.14) | ||
| Unknown LVSI | 162 | 75.7 (68.3–81.6) | 1.12/1.08 (0.70–1.67) | 86.8 (80.2–91.3) | 1.05/1.02 (0.56–1.86) | 76.6 (69.1–82.6) | 1.37/1.38 (0.86–2.21) | ||
| No LN resection | 248 | 69.6 (63.4–74.9) | 81.9 (76.2–86.3) | 75.9 (69.9–80.9) | |||||
| Negative LNs | 213 | 78.9 (72.8–83.8) | 0.67§/0.60§ (0.40–0.89) | 86.4 (80.9–90.4) | 0.76/0.56§ (0.34–0.94) | 76.8 (70.4–82.0) | 0.95/0.80 (0.53–1.20) | ||
| Treatment factors† | |||||||||
| Simple hysterectomy | 363 (78.7) | 73.7 (68.9–77.9) | 84.4 (80.0–87.8) | 76.7 (71.9–80.8) | |||||
| Radical hysterectomy | 73 (15.8) | 69.9 (57.9–79.0) | 1.13/1.70 (0.98–2.96) | 79.9 (68.4–87.6) | 1.29/1.65 (0.82–3.29) | 70.5 (58.4–79.7) | 1.27/1.39 (0.81–2.39) | ||
| Unknown type of hysterectomy | 25 (5.4) | 88.0 (67.3–96.0) | 0.42/0.68 (0.21–2.20) | 91.7 (70.6–97.9) | 0.51/0.82 (0.19–3.45) | 87.5 (66.1–95.8) | 0.49/0.57 (0.17–1.83) | ||
| No LN resection | 248 (53.8) | 69.6 (63.4–74.9) | 81.9 (76.2–86.3) | 75.9 (70.0–80.9) | |||||
| LN resection | 213 (46.2) | 78.9 (72.8–83.8) | 0.67§/0.50§ (0.31–0.81) | 86.4 (80.9–90.4) | 0.76/0.53‡ (0.31–0.99) | 76.8 (70.4–82.0) | 0.95/0.59§ (0.36–0.97) | ||
| No postoperative EBRT | 344 (74.6) | 71.7 (66.6–76.1) | 84.3 (79.8–87.8) | 74.4 (69.3–78.8) | |||||
| Postoperative EBRT | 117 (25.4) | 80.3 (71.9–86.5) | 0.66/0.66 (0.39–1.11) | 83.4 (75.3–89.1) | 1.06/0.89 (0.47–1.68) | 81.7 (73.4–87.7) | 0.67/0.47§ (0.26–0.82) | ||
| No postoperative chemotherapy | 411 (89.2) | 72.9 (68.4–77.0) | 83.5 (79.4–86.8) | 75.2 (70.6–79.2) | |||||
| Postoperative chemotherapy | 50 (10.9) | 81.7 (67.8–90.0) | 0.63/0.59 (0.28–1.23) | 88.9 (75.3–95.2) | 0.60/0.48 (0.18–1.27) | 85.4 (71.8–92.8) | 0.55/0.37§ (0.17–0.84) | ||
ASA, American Society of Anesthesiologists; aHR, adjusted hazard ratio; CI, confidence interval; EBRT, external beam radiotherapy; HR, hazard ratio; LN, lymph node; LVSI, lymphovascular space invasion.
*Adjusted for the other prognostic factors, age, and ASA; †Adjusted for the other treatment factors and age, ASA, grades 1, 2, 3, unfavorable tumor type; ‡p<0.001, §p<0.05.