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. 2019 Sep 26;31(2):e19. doi: 10.3802/jgo.2020.31.e19

Table 2. The relationship between clinical parameters or pathologic characteristics and the frequency of PD-L1 reactivity before or after the starting of CIRT.

Variables Total No. of patients Pre-CIRT PD-L1 expression p-value Post-12Gy-C PD-L1 expression p-value
Positive Negative Positive Negative
No. of patients 33 15 18 22 11
Age (yr) 0.227 0.806
≤60 17 6 11 11 6
>60 16 9 7 11 5
Clinical stage 0.135 0.314
≤IIB 13 8 5 10 3
≥III 20 7 13 12 8
Histological subclassification 0.381 0.706
Adenocarcinoma 29 14 15 19 10
Adenosquamous carcinoma 4 1 3 3 1
Maximum tumor size (cm) 0.898 1.000
≤5.3 18 8 10 12 6
>5.3 15 7 8 10 5
Lymph node metastasis 0.515 0.801
Positive 13 5 8 9 4
Negative 20 10 10 13 7

CIRT, carbon-ion radiotherapy; PD-L1, programmed cell death-ligand 1.