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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: J Leukoc Biol. 2019 Oct 14;107(3):379–391. doi: 10.1002/JLB.3MIR0919-191R

Figure 2. Schematic outline of mutations in the domains of NLRP3 and PYRIN.

Figure 2.

(A) Schematic representation of residue substitutions in the NLRP3 protein and reported point mutations. Mutations reported to be involved in Muckle-Wells syndrome and familial cold autoinflammatory syndrome (FCAS) are highlighted in red and blue, respectively.

(B) The domain organization of human PYRIN, indicating the four major domains and residue substitutions. Mutations reported to be involved in familial Mediterranean fever (FMF) are highlighted in red.