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. Author manuscript; available in PMC: 2020 Jun 9.
Published in final edited form as: Mucosal Immunol. 2019 Dec 9;13(2):271–282. doi: 10.1038/s41385-019-0240-7

Figure 6: GAPs support tolerance to dietary antigen and tolerance to luminal antigens in the distal colon.

Figure 6:

A) Quantification and B) images of footpad swelling following the induction of oral tolerance by dietary Ova, Ova immunization, and Ova footpad challenge in mice lacking goblet cells (Math1f/f vil-Cre-ERT2 mice) and their littermate controls. Quantification of footpad swelling following dietary Ova, Ova immunization, and Ova footpad challenge in C) mice lacking EGFR in goblet cells (EGFRf/fMath1Cre*PR mice) and their littermate controls treated with mEGF and in D) mice lacking mAChR4 in goblet cells (mAChR4f/f Math1Cre*PR mice) and littermate controls. E) Quantification of footpad swelling following the induction of tolerance by Ova enema, Ova immunization, and Ova footpad challenge in mice lacking goblet cells (Math1f/f vil-Cre-ERT2 mice) and their littermate controls. F-I) Serum IFNγ in mice treated as in A-E 24 hours following footpad challenge. * = P < 0.05. Data is presented as the mean +/− SEM. Each data point represents an individual mouse.